Pitt took advantage of a pass-interference penalty at the goal line to extend its lead over Eastern Michigan to 21-3 after three quarters.
A Bill Stull pass to Marcel Pestano drew a flag when cornerback Lyle Garrison interfered with the play, drawing a 15-yard penalty that gave Pitt the ball at the EMU 21.
A third-down pass to tight end John Pelusi was good for a first down, and Shane Brooks scored his second touchdown of the game on a 1-yard run with 9:11 remaining to cap an 11-play, 60-yard drive.
Stull injured his right thumb later in the quarter and replaced by redshirt freshman Kevan Smith. Stull had X-rays on the thumb, which required five stitches during training camp, and his return is questionable.